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Article History

Received: 24 June 2026

Accepted: 17 August 2026

First Online: 27 August 2026

Declarations

Ethics approval and consent to participate: Both the patient and her parents agreed to off-label treatment with metreleptin and provided written informed consent. They also consented to the use of the data. Any evaluation and publication of the data occurred exclusively in pseudonymised form (i.e., no personal identification can be made on the basis of these data alone). In accordance with the principles of Good Scientific Practice, the Ethics Committee of Rostock University Medical Center was informed retrospectively about the publication of these clinical data (registration number A2025-0021), and no ethical objections to the publication were raised.

Consent for publication: Written informed consent for publication of this case report and any accompanying images and data was obtained from the patient and, as the patient was a minor at the time of treatment, from her parents/legal guardians.

Competing interests: The authors declare no competing interests.