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Article History

Received: 2 March 2020

Accepted: 11 November 2020

First Online: 23 November 2020

Ethics approval and consent to participate

: The study was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice Guidelines. Before starting the study, written informed consent was obtained from all patients. The protocol was approved by the Ethics Committee of Hospital Clinic: Comité Ético de Investigación Clínica del Hospital Clínic i Provincial de Barcelona, Spain (Reference number: HCB/2014/0705).

: Not applicable.

: Dr. Angel Artal has nothing to declare. Dr. Dolores Isla has nothing to declare. Dr. Enric Carcereny has nothing to declare. Dr. Juan Coves reports personal fees from boehringer ingelheim, personal fees from BMS, personal fees from Roche, personal fees from ASTRAZENECA, personal fees from NOVARTIS, personal fees from MSD, personal fees from LILLY, outside the submitted work; Dr. Enriqueta Felip reports personal fees from ABBVIE, personal fees from ASTRA ZENECA, personal fees from BERGENBIO, personal fees from BLUE PRINT MEDICINES, personal fees from BOEHRINGER INGELHEIM, personal fees from BRISTOL-MYERS SQUIBB, personal fees from CELGENE, personal fees from ELI LILLY, personal fees from GUARDANT HEALTH, personal fees from JANSSEN, personal fees from MEDSCAPE, personal fees from MERCK KGaA, personal fees from MERCK SHARP & DOHME, personal fees from NOVARTIS, personal fees from PFIZER, personal fees from priME ONCOLOGY, personal fees from ROCHE, personal fees from SAMSUNG, personal fees from TAKEDA, personal fees from TOUCHTIME, outside the submitted work; and Board: Grífols (Independent Member). Dr. Javier De castro reports other from ASTRA ZENECA, other from BOEHRINGER INGELHEIM, other from BRISTOL MYERS SQUIBB, other from MERCK SHARP AND DOHME, other from HOFFMANN ROCHE, other from TAKEDA, other from NOVARTIS, other from PFIZER, outside the submitted work. Dr. Jose Luis Gonzalez Larriba has nothing to declare. Dr. Jordi Remon reports other from MSD, other from BOEHRINGER, other from PFIZER, personal fees and other from OSE IMMUNOTHERAPEUTICS, other from BMS, other from ASTRAZENECA, other from ROCHE, outside the submitted work. Dr. Manuel Domine reports personal fees from Abbvie, personal fees from Astra-Zeneca, personal fees from BMS, personal fees from Boehringer Ingelheim, personal fees from Celgene, personal fees from MSD, personal fees from Pfizer, personal fees from Roche, outside the submitted work. Dr. Margarita Majem reports grants from ROCHE, during the conduct of the study; personal fees from ROCHE, grants from BMS, personal fees from MSD, personal fees and other from ASTRA ZENECA, outside the submitted work; Dr. Nuria Viñolas reports grants from Roche, during the conduct of the study; personal fees from Roche, other from BMS, personal fees from Pfizer, other from Boeringher ingelheim, personal fees and other from Lilly, other from Astra zeneca, outside the submitted work. Dr. Pilar Garrido reports grants from ROCHE, during the conduct of the study; other from MSD, personal fees and other from BMS, personal fees and other from BOERINGHER INGELHEIM, personal fees and other from PFIZER, personal fees and other from NOVARTIS, other from LILLY, other from GUARDANT HEALTH, other from ABBVIE, personal fees and other from ASTRA ZENECA, other from SYSMEX, other from BLUE PRINT, other from TAKEDA, personal fees from GILEAD, personal fees from ROVI, personal fees and other from ROCHE, outside the submitted work. Dr. Pilar Lianes has nothing to declare. Dr..Rosario Garcia Campelo reports grants from Roche, during the conduct of the study; personal fees and other from Roche, personal fees and other from BMS, personal fees and other from MSD, personal fees and other from PFIZER, personal fees and other from LILLY, personal fees and other from ASTRA ZENECA, personal fees and other from TAKEDA, personal fees from NOVARTIS, personal fees and other from BOERINGHER INGELHEIM, outside the submitted work.