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Analysis of potential molecular targets and mechanisms of brominated flame retardants in causing osteoarthritis using network toxicology, machine learning, SHAP analysis, and molecular dynamics simulation

Crossref DOI link: https://doi.org/10.1186/s40360-025-00990-4

Published Online: 2025-08-18

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Liu, Yu

Shen, Guohang

Xia, Zidong

Wang, Ruoyan

Dai, Yupei
License Information

Text and Data Mining valid from 2025-08-18

Version of Record valid from 2025-08-18
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Article History

Received: 17 June 2025

Accepted: 13 August 2025

First Online: 18 August 2025

Declarations

:

: Not applicable. This study exclusively utilized publicly available, de‑identified bioinformatics datasets and did not involve the collection of new data from human participants or animals; therefore, no ethics committee approval or informed consent was required.

: Not applicable.

: The authors declare no competing interests.

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