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Association between daily dose of dipeptidyl peptidase-4 inhibitors and change in glycated hemoglobin in patients with type 2 diabetes: interpretation of mixed-effects machine-learning models using electronic medical records

Crossref DOI link: https://doi.org/10.1186/s40360-025-01055-2

Published Online: 2025-11-22

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hayakawa, Takashi

Akimoto, Hayato

Nagashima, Takuya

Minagawa, Kimino

Takahashi, Yasuo

Asai, Satoshi
Funding

Funding for this research was provided by:

Japan Society for the Promotion of Science (JP24K18341)

Japan Agency for Medical Research and Development (JP223fa627011)
License Information

Text and Data Mining valid from 2025-11-22

Version of Record valid from 2025-12-30
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Article History

Received: 11 September 2025

Accepted: 20 November 2025

First Online: 22 November 2025

Declarations

:

: The project was approved by the Ethics Committee of Nihon University School of Medicine (approval number: 2024-05).

: Not applicable.

: The authors declare no competing interests.

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