de Barrios, Oriol
Ocón-Gabarró, Ingrid
Gusi-Vives, Mar
Collazo, Olga
Meler, Ainara
Romecín, Paola A.
Martínez-Moreno, Alba
Tejedor, Juan Ramón
Fraga, Mario F.
Schneider, Pauline
Bardini, Michela
Cazzaniga, Giovanni
Marschalek, Rolf
Stam, Ronald W.
Bueno, Clara
Menéndez, Pablo
Parra, Maribel
Funding for this research was provided by:
Fundación Científica Asociación Española Contra el Cáncer (POSTD20024DEBA)
Ministerio de Ciencia e Innovación (RYC2021-031197-I, MICINN, EUR2019-103835)
José Carreras Leukämie-Stiftung (DJCLS/07R/2022, DJCLS/07R/2022, DJCLS/07R/2022)
Agencia Estatal de Investigación (PRE2018-083183)
Fight Kids Cancer Funding Programme (Cure2MLL, Cure2MLL, Cure2MLL)
Instituto de Salud Carlos III (PI20/00822, PI21/01451)
Article History
Received: 11 February 2025
Accepted: 9 July 2025
First Online: 28 July 2025
Declarations
:
: The experimental work proposed in this study involving primary human samples has been approved by the IRB board at Germans Trias i Pujol hospital, at Can Ruti Campus in Badalona (approval code: PI21/01451). Patient samples from KMT2A germline and t(4;11) pro-B-ALL were obtained with the authorization from patients’ legal representatives. All animal procedures involved are approved by the Animal Research Ethics Committee of CMCiB-IGTP facility (20–004-JRU-P5) and the Animal Research Commission from the Government of Catalonia (CEA/10473_MR2/P5).
: All contributing authors have agreed to publish this manuscript.
: PM is cofounder of OneChain Immunotherapeutics, a spin-off company focused on CAR-T cells with no connection with the present work. The rest of the authors declare no competing interests.