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Article History

Received: 6 February 2019

Accepted: 28 March 2019

First Online: 24 April 2019

Ethics approval and consent to participate

: Data and samples were collected on a DF-HCC institutionally review board approved protocol (05–042).

: Consent for publication obtained.

: Dr. Schoenfeld reports grants, personal fees and non-financial support from Bristol-Myers Squibb, grants from Merck, personal fees and non-financial support from AstraZeneca, personal fees and non-financial support from Debiopharm, personal fees from Nanobiotix, personal fees from Tilos Therapeutics, grants from Regeneron, all outside the submitted work.Dr. Nishino reports she is a Consultant to Toshiba Medical Systems, WorldCare Clinical, Daiichi Sankyo; Research grant from Merck Investigator Studies Program, Canon Medical Systems, AstraZeneca; and Honorarium from Bayer, Roche.Dr. Mak reports AstraZeneca (Scientific Advisory Board), NewRT (honorarium).Dr. Hodi reports grants, personal fees and consulting from Bristol-Myers Squibb, personal fees from Merck, personal fees from EMD Serono, personal fees from Novartis, personal fees from Celldex, personal fees from Amgen, personal fees from Genentech/Roche, personal fees from Incyte, personal fees from Apricity, personal fees from Bayer, personal fees from Aduro, personal fees from Partners Therapeutics, personal fees from Sanofi, personal fees from Pfizer, personal fees from Pionyr, is an upaid advisor for 7 Hills Pharma, personal fees from Verastem, other from Torque, personal fees from Compass Therapeutics, personal fees from Takeda, outside the submitted work; In addition, Dr. Hodi has a patent Methods for Treating MICA-Related Disorders (#20100111973) with royalties paid, a patent Tumor antigens and uses thereof (#7250291) issued, a patent Angiopoiten-2 Biomarkers Predictive of Anti-immune checkpoint response (#20170248603) pending, a patent Compositions and Methods for Identification, Assessment, Prevention, and Treatment of Melanoma using PD-L1 Isoforms (#20160340407) pending, a patent Therapeutic peptides (#20160046716) pending, a patent Therapeutic Peptides (#20140004112) pending, a patent Therapeutic Peptides (#20170022275) pending, a patent Therapeutic Peptides (#20170008962) pending, a patent THERAPEUTIC PEPTIDES Patent number: 9402905 issued, and a patent METHODS OF USING PEMBROLIZUMAB AND TREBANANIB pending.

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