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PD-1 silencing impairs the anti-tumor function of chimeric antigen receptor modified T cells by inhibiting proliferation activity

Crossref DOI link: https://doi.org/10.1186/s40425-019-0685-y

Published Online: 2019-08-07

Published Print: 2019-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wei, Jianshu

Luo, Can

Wang, Yao

Guo, Yelei

Dai, Hanren

Tong, Chuan

Ti, Dongdong

Wu, Zhiqiang

Han, Weidong
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (81830002, 31870873, 81703044, 81502679)

National Key Research and Development Program of China (2016YFC1303501, 2016YFC1303504, 2017YFC0909803)
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Article History

Received: 26 November 2018

Accepted: 18 July 2019

First Online: 7 August 2019

Ethics approval and consent to participate

: All animal experiments have been approved by the Institutional Animal Care and Use Committee (IACUC) of Chinese PLA General Hospital (PLAGH), and all the procedures were performed in accordance with the guidelines of IACUC of PLAGH.

: No individual data were used in this study.

: The authors declare that they have no competing interests.