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Article History

Received: 31 May 2019

Accepted: 20 September 2019

First Online: 24 October 2019

Ethics approval and consent to participate

: The trial was conducted in accordance with the Declaration of Helsinki and the International Council for Harmonisation Guideline for Good Clinical Practice. The protocol was approved by the institutional review board or independent ethics committee of each centre, and all patients provided written informed consent before enrolment.

: Not applicable.

: UV reports research funding from Novartis, Exelixis, and Pfizer; consultancy remuneration from Bayer, Exelixis, Pfizer, Bristol-Myers Squibb, and EMD Serono; and honoraria from Sanofi, Pfizer, Bristol-Myers Squibb, Bayer, and Exelixis. PS reports consultancy or advisory remuneration from Blueprint Medicines, Eisai, Ellipses Pharma, Eli Lilly, Loxo Oncology, Deciphera Pharmaceuticals, Merck KGaA, Servier, Genmab, Adaptimmune, Intellisphere, Transgene, and Plexxikon, and research funding from Blueprint Medicines, Boehringer Ingelheim, CoBioRes NV, Eisai, Exelixis, G1 Therapeutics, Eli Lilly, Novartis, PharmaMar, and Plexxikon. AR reports honoraria and travel expenses from Bristol-Myers Squibb, Novartis, Ipsen, Astra Zeneca, and Pfizer; and consultancy or advisory remuneration from Bristol-Myers Squibb, Ipsen, Novartis, Pfizer, Astra Zeneca, and Roche. JCM reports speakers bureau services for Boehringer Ingelheim and Merck KGaA; travel expenses from Amgen, Eisai, Merck KGaA, and VentiRx Pharmaceuticals; and other relationship with Merck KGaA. MS reports research funding from Merrimack. DZ reports employment with and research funding from Merck KGaA. SG and MB report employment with Merck KGaA. JLG reports research funding from Astellas and Medivation, Bavarian Nordic, Merck KGaA, NantBioScience, and Pfizer. All remaining authors have declared no competing interests.