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Article History

Received: 2 August 2018

Accepted: 4 August 2018

First Online: 9 August 2018

Ethics approval and consent to participate

: Animal work was conducted with the approval of the ethical committee of the University of Barcelona (CEEA) and theDirecció General de Polítiques Ambientals i Medi Natural,Departament de Territori i Sostenibilitat de la Generalitat de Catalunya. Studies complied with the “Principles of laboratory animal care” (NIH publication No. 86–23, revised 1985), and the Spanish National law (Real Decreto 53/2013). Animal work is reported according to the ARRIVE guidelines.The brain tissue of three ischemic stroke patients who died at the Stroke Unit of Hospital Clínic de Barcelona 24 h after stroke onset was used in this study. We obtained written consent from the families for tissue removal after death for diagnostic and research purposes at the Neurological Tissue bank of the Biobank-Hospital Clínic-Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). The study had the approval of the Ethics Committee of Hospital Clínic de Barcelona (CEIm).

: Not applicable

: The authors declare that no conflict of interest exists.

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