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Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation

Crossref DOI link: https://doi.org/10.1186/s40478-018-0600-7

Published Online: 2018-09-24

Published Print: 2018-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wong, Maggie M. K.

Hoekstra, Stephanie D.

Vowles, Jane

Watson, Lauren M.

Fuller, Geraint

Németh, Andrea H.

Cowley, Sally A.

Ansorge, Olaf

Talbot, Kevin

Becker, Esther B. E. http://orcid.org/0000-0002-5238-4902
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Article History

Received: 13 September 2018

Accepted: 14 September 2018

First Online: 24 September 2018

Ethics approval and consent to participate

: The human iPSC lines used for this study were derived from human skin biopsy fibroblasts, following signed informed consent, with approval from the National Research Ethics Service Committee, South Central – Southampton B (REC reference number 12/SC/0106). Human tissues were collected and studied under REC reference 15/SC/0639 of the Oxford Brain Bank, an HTA-licensed research tissue bank of the University of Oxford. The human PBMCs used for this study were obtained following signed informed consent, with approval from the West Midlands – Coventry and Warwickshire Research Ethics Committee (REC reference number 17/WM/0333).

: Consent for publication has been obtained.

: The authors declare that they have no competing interests.

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