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Article History

Received: 16 November 2018

Accepted: 17 November 2018

First Online: 29 November 2018

Ethics approval

: Animal experiments were performed in compliance with and with the approval of the local ethics committee (agreement 2,015,101,320,441,671, 2016–2021), standards for the care and use of laboratory animals, and the French and European Community guidelines as well as the Massachusetts General Hospital’s Institutional Animal Care and Use Committee.All human tissues come from the Lille Neurobank and the Massachusetts Alzheimer’s Disease Research center and written consent forms have been obtained accordingly to the local legislations and ethical committees. Human brains extracts were obtained from the Massachusetts Alzheimer’s Disease Research Center (grant number P50 AG005134, under IRB protocol 1999P003693) and the Lille Neurobank (CRB/CIC1403 Biobank, BB-0033-00030, agreement DC-2008-642) fulfilling criteria of the local laws and regulations on biological resources with donor consent, data protection and ethical committee review.

: All Authors have seen and approved the manuscript being submitted.

: The authors declare no conflicts of interest.

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