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Article History

Received: 6 December 2018

Accepted: 25 January 2019

First Online: 7 February 2019

Ethics approval and consent to participate

: Ethical approvals were granted by local research ethics committees of the Newcastle upon Tyne Foundation Hospitals Trust. Permission for use of brains for post-mortem research was also granted by consent from next-of-kin or family. All the brain tissues were retained in and obtained from the Newcastle Brain Tissue Resource.

: All the authors have approved publication and see various versions of the manuscript.

: The authors declare that they have no competing interests.

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