Funding for this research was provided by:
Medical Research Council (G0500247)
Alzheimer's Research UK (PG2013-022)
Received: 6 December 2018
Accepted: 25 January 2019
First Online: 7 February 2019
Ethics approval and consent to participate
: Ethical approvals were granted by local research ethics committees of the Newcastle upon Tyne Foundation Hospitals Trust. Permission for use of brains for post-mortem research was also granted by consent from next-of-kin or family. All the brain tissues were retained in and obtained from the Newcastle Brain Tissue Resource.
: All the authors have approved publication and see various versions of the manuscript.
: The authors declare that they have no competing interests.
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