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Article History

Received: 26 October 2019

Accepted: 2 December 2019

First Online: 21 December 2019

Ethics approval and consent to participate

: This study employed tissue collected by the Banner Sun Health Research Institute Brain and Body donation program from consented donors in Arizona, U.S.A. The operation of the BBDP in terms of collecting clinical data has been continuously approved since initiation. Current approval was carried out by Western IRB (Puyallup, WA). The consenting form for tissue donation allows the sharing of tissue with qualified researchers in research projects. The use of anonymized human tissue for research in the U.S.A. is not considered human subject research under Federal regulations exemption 4 (C.F.R 46.101). Most of the tissue samples described in this study were transferred to Japan when DGW moved institution, under a material transfer agreement (MTA) between Banner Health and Shiga University of Medical Science. Tissue studies carried out in Japan are considered human research with these studies being approved by Shiga University of Medical Science Ethical Committee (Certificate no. 29–114). The identifiable information on each subject is not known to personnel carrying out the research in this report (AM, IT, JPB, LFL and DGW).

: All listed authors have reviewed the completed manuscript and have consented to publication of this report.

: Authors report no competing interests.