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Article History

Received: 14 January 2022

Accepted: 19 January 2022

First Online: 5 February 2022

Declarations

:

: The study was approved by the Mayo Clinic and Olmsted Medical Center institutional review boards and written informed consent was obtained from all participants or their qualified caregivers.

: Not applicable.

: The authors report no competing interests related to the submitted manuscript. Dr. Raghavan reports no relevant financial disclosures. Mr. Przybelski reports no relevant financial disclosures. Dr. Reid reports no relevant financial disclosures. Mr. Lesnick reports no relevant financial disclosures. Dr. Ramanan reports no relevant financial disclosures. Dr. Hugo reports no relevant financial disclosures. Dr. Melissa reports no relevant financial disclosures. Dr. Knopman serves on a Data Safety Monitoring Board for the DIAN study. He serves on a Data Safety monitoring Board for Biogen, but receives no personal compensation. He is an investigator in clinical trials sponsored by Biogen, Lilly Pharmaceuticals, and the University of Southern California. He serves as a consultant for Roche, Samus Therapeutics, Third Rock and Alzeca Biosciences but receives no personal compensation. Dr. Graff-Radford serves as an assistant editor for Neurology and receives research support from the NIH. Dr. Jones receives research support from NIH. Mrs. Matchett reports no relevant financial disclosures. Dr. Lowe consults for Bayer Schering Pharma, Piramal Life Sciences, Life Molecular Imaging, Eisai Inc., AVID Radiopharmaceuticals, and Merck Research and receives research support from GE Healthcare, Siemens Molecular Imaging, AVID Radiopharmaceuticals, and the NIH (NIA, NCI). Dr. Mielke serves as a consultant for Biogen and Brain Protection Company and receives research funds from NIH and DOD. Dr. Machulda receives research support from NIH. Dr. Petersen serves as a consultant for Roche Inc., Merck Inc., and Biogen, Inc. He serves on the Data Safety monitoring Board for Genentech, Inc and receives royalty from Oxford University Press and UpToDate. Dr. Kantarci served on the data safety monitoring board for Takeda Global Research and Development Center, Inc.; receives research support from Avid Radioparmaceuticals and Eli Lilly, and receives funding from NIH and Alzheimer’s Drug Discovery Foundation. Dr. Whitwell receives research support from NIH. Dr. Josephs receives research support from NINDS, NIA and NIDCD. Dr. Jack serves on an independent data monitoring board for Roche, has served as a speaker for Eisai, and consulted for Biogen, but he receives no personal compensation from any commercial entity. He receives research support from NIH and the Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Clinic. Dr. Vemuri received speaker fees from Miller Medical Communications, Inc. and receives research support from the NIH.