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Authors
Laszlo, Zsofia I. http://orcid.org/0000-0001-5317-1207
Hindley, Nicole
Sanchez Avila, Anna
Kline, Rachel A.
Eaton, Samantha L.
Lamont, Douglas J.
Smith, Colin
Spires-Jones, Tara L.
Wishart, Thomas M.
Henstridge, Christopher M. http://orcid.org/0000-0002-0393-180X
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Funding
Funding for this research was provided by:
Alzheimer’s Research UK (ARUK-EG2019B-003)
H2020 European Research Council (681181)
Biotechnology and Biological Sciences Research Council (BBS/E/D/10002071)
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Article History
Received: 29 September 2022
Accepted: 30 September 2022
First Online: 29 October 2022
Declarations
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: Patients were recruited through the Scottish Motor Neurone Disease Register and data collected in the CARE-MND database (Clinical Audit Research and Evaluation). Ethical approval for this register was obtained from Scotland A Research Ethics Committee 10/MRE00/78 and 15/SS/0216. All clinical data were subsequently extracted from the CARE-MND database. Use of patient samples for genetic profiling has been approved by the Chief Scientist Office Scotland; MREC/98/0/56 1989–2010, 10/MRE00/77 2011–2013, 13/ES/0126 2013–2015, 15/ES/0094 2015-present. Use of human tissue for post-mortem studies has been reviewed and approved by the Edinburgh Brain Bank ethics committee and the ACCORD medical research ethics committee, AMREC (ACCORD is the Academic and Clinical Central Office for Research and Development, a joint office of the University of Edinburgh and NHS Lothian, approval number 15-HV-016). The Edinburgh Brain Bank has research ethics committee (REC) approval (21/ES/0087).
: All authors have read the manuscript and agreed with its submission.
: The authors declare that they have no Competing interests.
