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Oligodendrocyte-specific overexpression of human alpha-synuclein results in elevated MBP levels and inflammatory responses in TgM83 mice, mimicking the pathological features of multiple system atrophy

Crossref DOI link: https://doi.org/10.1186/s40478-025-02014-y

Published Online: 2025-05-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Liu, Sam Chi-Hao

Chang, Koping

Chen, Meng-Ling

Kuo, Ming-Che

Wang, Teh-Cheng

Wu, Ruey-Meei
Funding

Funding for this research was provided by:

National Science and Technology Council (113-2811-B-002-108)

National Taiwan University Hospital (MS329)
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Text and Data Mining valid from 2025-05-07

Version of Record valid from 2025-05-07
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Article History

Received: 6 March 2025

Accepted: 22 April 2025

First Online: 7 May 2025

Declarations

:

: All human brain tissue was donated to the Department of Pathology following donor and donor family consent, and its use in this study was approved by the National Taiwan University Hospital Research Ethics Committee (reference number 202008001RIND and 202410088RINC).

: Not applicable.

: The authors declare no competing interests.

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