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Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life

Crossref DOI link: https://doi.org/10.1186/s40478-025-02022-y

Published Online: 2025-05-29

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Latina, Valentina

De Introna, Margherita

Malerba, Francesca

Florio, Rita

Balzamino, Bijorn Omar

Di Natale, Giuseppe

Sciacca, Michele Francesco Maria

Pappalardo, Giuseppe

Micera, Alessandra

Pignataro, Annabella

Calissano, Pietro

Amadoro, Giuseppina https://orcid.org/0000-0003-2080-2951
Funding

Funding for this research was provided by:

Italian Ministry of Health (RC278859, RF-2021-12374301)

Fondazione Roma

Fondo Ordinario Enti funds in the framework of a collaboration agreement between the Italian National Research Council and EBRI (FOE D.M865/2019, FOE D.M865/2019)

Alzheimer's Association Research Grant (Proposal ID: 971925)
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Article History

Received: 13 March 2025

Accepted: 30 April 2025

First Online: 29 May 2025

Declarations

:

: All animal experiments were complied with the ARRIVE guidelines and were carried out in accordance with the etical guidelines, the European Council Directive (2010/63/EU) and the Italian Animal Welfare legislation (D.L. 26/2014). The experimental approval was obtained from the Italian Ministry of Health (Authorization n. 1038–2020-PR; Authorization n. 419/2023-PR). This study was carried out according to the principles of the 3Rs (Replacement, Reduction and Refinement) to minimize animal suffering and to reduce the number of animals used.

: All authors have approved the manuscript and agree with its submission.

: The authors declare there are no competing interests.

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