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Authors
Popek, Mariusz
Obara-Michlewska, Marta
Szewczyk, Łukasz Mateusz
Kołodziej, Marcin
Perlejewski, Karol
Verkhratsky, Alexei
Albrecht, Jan
Zielińska, Magdalena
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Funding
Funding for this research was provided by:
National Science Centre in Poland (SONATA 19 (No 2023/51/D/NZ5/02035)
Statutory funds from Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (No 13)
Statutory funds from Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (No 13)
Statutory funds from Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (No 13)
Statutory funds from Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (No 13)
Narodowe Centrum Nauki (MINIATURA 3 (No 2019/03/X/NZ4/00623)
Spanish MICINN (PID2022-143020OB-I00)
Basque Government (IT1551-22)
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Article History
Received: 28 February 2025
Accepted: 21 May 2025
First Online: 31 May 2025
Declarations
:
: Not applicable.
: Not applicable.
: The authors declare no competing interests.
: Hepatic encephalopathy is associated with astrocyte remodelling manifested by swelling of the soma and primary branches together with atrophy of distal branches and leaflets; the latter retract from synapses, thus affecting neurotransmission and contributing to the reduced neuronal activity. Astrocyte remodelling was linked to a decrease of plasmalemma-cytoskeleton linker phosphorylated ezrin (Phos-ERM), actin modulator profilin-1 (PFN1), and water channel aquaporin 4 (AQP4).
: Additional materials are available at Acta Neuropathologica Communications online.
