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Authors
Popek, Mariusz
Obara-Michlewska, Marta
Szewczyk, Łukasz Mateusz
Kołodziej, Marcin
Perlejewski, Karol
Verkhratsky, Alexei
Albrecht, Jan
Zielińska, Magdalena
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Funding
Funding for this research was provided by:
National Science Centre in Poland (SONATA 19 (No 2023/51/D/NZ5/02035)
Statutory funds from Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (No 13, No 13, No 13, No 13)
Narodowe Centrum Nauki (MINIATURA 3 (No 2019/03/X/NZ4/00623)
Spanish MICINN (PID2022-143020OB-I00)
Basque Government (IT1551-22)
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Article History
Received: 28 February 2025
Accepted: 21 May 2025
First Online: 31 May 2025
Declarations
:
: Not applicable.
: Not applicable.
: The authors declare no competing interests.
: Hepatic encephalopathy is associated with astrocyte remodelling manifested by swelling of the soma and primary branches together with atrophy of distal branches and leaflets; the latter retract from synapses, thus affecting neurotransmission and contributing to the reduced neuronal activity. Astrocyte remodelling was linked to a decrease of plasmalemma-cytoskeleton linker phosphorylated ezrin (Phos-ERM), actin modulator profilin-1 (PFN1), and water channel aquaporin 4 (AQP4).
: Additional materials are available at Acta Neuropathologica Communications online.
