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Kcnq2 R213 knock-in mice reveal variant- and region-specific mechanisms underlying self-limited familial neonatal-infantile epilepsy and early infantile developmental and epileptic encephalopathy

Crossref DOI link: https://doi.org/10.1186/s40478-026-02264-4

Published Online: 2026-02-25

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Nishijo, Takuma

Hamada, Nanako

Suliman-Lavie, Reut

Tabata, Hidenori

Ito, Hidenori

Iwamoto, Ikuko

Shifman, Sagiv

Nagata, Koh-ichi
Funding

Funding for this research was provided by:

Japan Society for the Promotion of Science (JP23K14997)

Japan Society for the Promotion of Science (JP22H03049, JP22K19498)
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Text and Data Mining valid from 2026-02-25

Version of Record valid from 2026-03-31
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Article History

Received: 4 July 2025

Accepted: 16 February 2026

First Online: 25 February 2026

Declarations

:

: This study does not involve human participants, human data or human tissue. As to the animal experiments, we followed the fundamental guidelines for proper conduct of animal experiments and related activity in academic research institution under the jurisdiction of the Ministry of Education, Culture, Sports, Science and Technology, Japan. All the protocols for animal handling and treatment were reviewed and approved by the animal care and use committee of Institute for Developmental Research, Aichi Developmental Disability Center (approval number: 2019–013). All experiments were conducted in compliance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines. All methods, data presentation and statistical analyses were carried out in accordance with the TOP (Transparency and Openness Promotion) guidelines.

: Not applicable.

: The authors declare no competing interests.

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