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Age-dependent vascular and neurological characteristics of CADASIL are recapitulated in Notch3 mutant zebrafish, implicating a role for type IV collagen in disease progression

Crossref DOI link: https://doi.org/10.1186/s40478-026-02333-8

Published Online: 2026-06-03

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Kanoh, Tohgo

Oubayashi, Shiho

Furukawa, Kengo

Fujimoto, Kosuke

Inoue, Amane

Mizoguchi, Takamasa

Yamaguchi, Masashi

Takahashi-Nakaguchi, Azusa

Hasegawa, Yoshinori

Ohara, Osamu

Aoki, Ichio

Itoh, Motoyuki https://orcid.org/0000-0001-5017-2482
Funding

Funding for this research was provided by:

Japan Society for the Promotion of Science (JP25KJ0721)

Japan Society for the Promotion of Science (JP25K09486)

Japan Society for the Promotion of Science (JP18H02568)

Japan Science and Technology Agency (JPMJSP2109)

JSPS (JP21H02621)
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Text and Data Mining valid from 2026-06-03

Version of Record valid from 2026-08-10
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Article History

Received: 11 April 2026

Accepted: 15 May 2026

First Online: 3 June 2026

Declarations

Ethics approval and consent to participate: This study was approved by the Institutional Animal Care and Use Committee at Chiba University (nos 1–170, 2–174, 3–62, 4–6, 5–70, 6–86, 7–22, 30–442).

Consent for publication: All authors read and approved the final version of the manuscript.

Competing interests: The authors declare no competing interests.

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