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Nanopore-based DNA methylation profiling for rapid molecular classification of NOS/NEC CNS tumors: multi-institutional evaluation using FFPE archives and frozen tissues

Crossref DOI link: https://doi.org/10.1186/s40478-026-02359-y

Published Online: 2026-06-30

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hu, Wanming

Zhu, Jin

Li, Hang

Yu, Qiubo

Chen, Song

Ren, Qinglan

Wu, Jingxian

Cao, Youde

Hou, Yanghao
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (62271475 and 82102877)

Natural Science Foundation of Chongqing (CSTB2023NSCQ-BHX0105)
License Information

Text and Data Mining valid from 2026-06-30

Accepted Manuscript valid from 2026-06-30
More Information

Article History

Received: 12 February 2026

Accepted: 21 June 2026

First Online: 30 June 2026

Declarations

:

: The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committees of Chongqing Medical University and Sun Yat-sen University Cancer Center. All data were used solely for methodological validation; No results were reported back to patients or used for clinical decision-making.

: Not applicable. (No identifiable personal data are included in this manuscript.)

: The authors declare no competing interests.

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