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Aging is associated with behavioral alterations, lysosomal dysfunction, region-specific inflammation, and glutamatergic synaptic impairments in a Grn knockout mouse model of frontotemporal dementia

Crossref DOI link: https://doi.org/10.1186/s40478-026-02418-4

Published Online: 2026-09-11

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Bertasini, Chiara

Italia, Maria

Tavakolian Haghighi, Shima

Salzano, Sara

Sorio, Daniela

Murari, Matilde

Gottardo, Rossella

Galasso, Marilisa

Scupoli, Maria Teresa

Castagna, Annalisa

Cané, Stefania

Wahlberg, Lars U.

Gardoni, Fabrizio

Paolone, Giovanna https://orcid.org/0000-0002-4484-5529
Funding

Funding for this research was provided by:

Michael J. Fox Foundation (MJFF) for Parkinson’s Research (MJFF-021152)
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Text and Data Mining valid from 2026-09-11

Accepted Manuscript valid from 2026-09-11
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Article History

Received: 16 June 2026

Accepted: 25 August 2026

First Online: 11 September 2026

Declarations

Ethics approval and consent to participate: Not applicable.

Informed consent: Informed consent was not necessary.

Competing interests: The authors declare no competing interests.

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