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Association between early administration of mucoactive agents and in-hospital mortality in patients with pneumonia requiring mechanical ventilation: a nationwide cohort study

Crossref DOI link: https://doi.org/10.1186/s40560-025-00826-7

Published Online: 2025-10-16

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Sasaki, Akira

Nakajima, Mikio

Shinozaki, Tomohiro

Sasabuchi, Yusuke

Ohbe, Hiroyuki

Kaszynski, Richard H.

Kimura, Yuya

Morita, Kojiro

Goto, Tadahiro

Aiyama, Yuki

Nakayama, Izumi

Matsui, Hiroki

Fushimi, Kiyohide

Ochiai, Hidenobu

Yasunaga, Hideo
Funding

Funding for this research was provided by:

National Science Foundation (23AA2003 and 24AA2006)
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Article History

Received: 14 July 2025

Accepted: 21 September 2025

First Online: 16 October 2025

Declarations

:

: The present study was approved by The University of Tokyo Institutional Review Board [approval number, 3501-(5)]. Due to the anonymous nature of the database, the standard requirement for informed consent was waived for this study.

: Not applicable.

: The authors declare that they have no competing interests.

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