Kyriazopoulou, Evdoxia
Kotsaki, Antigone
Safarika, Asimina
Poulakou, Garyfallia
Milionis, Haralampos
Metallidis, Simeon
Adamis, Georgios
Fragkou, Archontoula
Rapti, Aggeliki
Del Vecchio, Pierluigi
Kalomenidis, Ioannis
Kitzoglou, Danae
Angheben, Andrea
Kainis, Ilias
Iliopoulou, Konstantina
Serino, Francesco Saverio
Bakakos, Petros
Tzavara, Vassiliki
Ioannou, Sofia
Dagna, Lorenzo
Dimakou, Katerina
Tzatzagou, Glykeria
Chini, Maria
Bassetti, Matteo
Kotsis, Vasileios
Tsoukalas, George
Selmi, Carlo
Nikolakopoulou, Sofia
Samarkos, Michael
Doumas, Michael
Masgala, Aikaterini
Papanikolaou, Ilias
Argyraki, Aikaterini
Akinosoglou, Karolina
Symbardi, Styliani
Panagopoulos, Periklis
Dalekos, George N.
Liesenfeld, Oliver
Sweeney, Timothy E.
Khatri, Purvesh
Giamarellos-Bourboulis, Evangelos J. https://orcid.org/0000-0003-4713-3911
Funding for this research was provided by:
Swedish Orphan Biovitrum
Inflammatix
Hellenic Institute for the Study of Sepsis
Article History
Received: 12 January 2025
Accepted: 23 June 2025
First Online: 30 June 2025
Declarations
:
: The SAVE-MORE trial (NCT04680949) was approved by the National Ethics Committee of Greece (approval 161/20) and by the Ethics Committee of the National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, in Rome (1 February 2021). All patients or their legal representatives provided written informed consent before enrollment.
: Not applicable.
: TS is an employee of and shareholder in Inflammatix, Inc. OL and PK are shareholders in Inflammatix, Inc. EJG-B reports honoraria from Abbott Products Operations, bioMérieux, Brahms GmbH, GSK, InflaRx GmbH, Sobi and Xbiotech Inc; independent educational grants from Abbott Products Operations, bioMérieux Inc, Johnson & Johnson, MSD, UCB, Swedish Orphan Biovitrum AB; and funding from the Horizon 2020 European Grants ImmunoSep and RISCinCOVID and the Horizon Health grants EPIC-CROWN-2, POINT and Homi-Lung (granted to the Hellenic Institute for the Study of Sepsis). The other authors declare no competing interests.