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Article History

Received: 3 October 2024

Accepted: 13 March 2025

First Online: 13 May 2025

Declarations

:

: This study protocol was approved by the MoH Health research ethics Committee (MOH; CERS 2022-03-044; approval date: 2 Mars 2022) and by the technical committee of clinical trials examination. The protocol is registered at Clinicaltrials.gov Protocol registration and results system (NCT05586139; ; registration date: 22 September 2022). Amendments to the study protocol will be submitted to the Ethics Committee, and the trial registry will be updated accordingly. This study will be conducted according to the principles of the Declaration of Helsinki. Before the participants’ enrollment, an explanation will be provided regarding the informed consent contents, study procedures, objectives, and potential outcomes and their participation are voluntary. All participants should provide an informed written consent form. All data will be handled with strict confidentiality, assuring the anonymity throughout the study.

: Not applicable.

: The authors declare no competing interests.