Article History
Received: 17 October 2017
Accepted: 8 January 2018
First Online: 20 February 2018
Ethics approval and consent to participate
: Experiments were performed according to the recommendations and policies of the National Standard of Russian Federation GOST R-53434-2009, under a protocol which had been previously approved by the Ethics Committee of the Saint-Petersburg Institute of Pharmacy JSC (Russia). All painful manipulations of the animals were conducted in accordance with regulatory standards (Directive 2010/63/EU of the European parliament and of the council of 22 September 2010 on the protection of animals used for scientific purposes).
: Jan Seibel, Meinolf Wonnemann and Martin D. Lehner are employees of Bionorica SE, Germany. Oliver Werz received funding from Bionorica SE, Germany. The authors declare that they have no further competing interests.