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Article History

Received: 21 October 2018

Accepted: 7 December 2018

First Online: 29 December 2018

Ethics approval and consent to participate

: All the animal testing procedures were in conformity with the Directive 2010/63/EU of the European Parliament and the Portuguese DL 113/2013. All the procedures were approved by the ICBAS-UP Animal Welfare Organism of the Ethics Committee (ORBEA) and by the Veterinary Authorities of Portugal (DGAV). Humane end points were followed in accordance to the OECD Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation (2000), and adequate measures were taken to minimize pain and discomfort considering human endpoints for animal suffering and distress. The interaction of Bonelike® in bone tissue was evaluated in 10 dogs and 4 cats.

: Not applicable.

: The authors report no financial or other conflicts relates to this report. The authors do not have conflict of interest with any of the materials or companies described in the manuscript. Although A Brandão is an employee of Biosckin, Molecular and Cell Therapies, S.A. this does not alter the adherence to policies on sharing data and materials.

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