Krüger, Dustin N.
Bosman, Matthias
Van Assche, Charles X.L.
Wesley, Callan D.
Cillero-Pastor, Berta
Delrue, Leen
Heggermont, Ward
Bartunek, Jozef
De Meyer, Guido R. Y.
Van Craenenbroeck, Emeline M.
Guns, Pieter-Jan
Franssen, Constantijn
Funding for this research was provided by:
European Union’s Horizon 2020 (No 858070, No 858070, No 858070, No 858070)
Fund for Scientific Research (FWO) Flanders (1S33720N)
Belgian Foundation against Cancer (2021-034, 2021-034)
senior clinical investigator grant (1804320N)
Koning Boudewijnstichting (Funds Pierre Masure, Alphonse & Marie Walckiers and De Winter-Vermant 2018, Funds Pierre Masure, Alphonse & Marie Walckiers and De Winter-Vermant 2018)
Article History
Received: 10 January 2024
Accepted: 10 June 2024
First Online: 22 June 2024
Declarations
:
: Animal Study: Use of animals was approved by the Ethical Committee of the University of Antwerp and was conducted in accordance with Directive 2010/63/EU file 2020-74, the ARRIVE guidelines, and the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (NIH Publication no.85-23, revised 1996).Welfare of animals was assessed daily by the animal caretakers and the principal researcher based on the scoring system of the Functional Observation Battery []. Criteria for humane euthanasia were as follows: Animals displaying clear signs of pain based on the scoring table, meeting specific score thresholds, or exhibiting significant weight loss (> 20%).Patient data: The study protocol for the procurement of biomaterials (blood samples and myocardial biopsies) was approved by the Ethical Committee (ECNR075 VARIA10) of the Onze-Lieve-Vrouw Hospital Aalst (Belgium). The IRB/EC of Aalst is officially recognized by the Belgian Authorities. All patients in whom myocardial biopsies were procured, were informed by the operating physician and provided written informed consent prior to the procedure. The indication for cardiac catheterization in the CTR-CVT group was always based on guidelines of the European Society of Cardiology.
: The authors declare no competing interests.