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Article History

Received: 30 August 2017

Accepted: 13 February 2018

First Online: 28 March 2018

Authors’ information

: The sponsor-investigators are Martin Siegemund, MD, Deputy Chief Physician, and Alexa Hollinger, MD, Medical Resident, Critical Care Fellow. The co-investigators are Franziska Jockers, MD, Thomas Schweingruber, MD, Lukas Gantner, MD, Katrin Ledergerber, MD, and Jonas Dominic Scheuzger, MD. Michael Dickenmann, MD, Markus Aschwanden, MD, Johann Knotzer, MD, and Jasper van Bommel, MD, are the project partners, serve as consultants and/or assist in data acquisition.

: This study is conducted in compliance with the protocol, the current version of the Declaration of Helsinki, the ICH-GCP or ISO EN 14155 (as far as applicable) as well as all national legal and regulatory requirements. Research Ethics Committee approval has been granted for this study by EKNZ (Ethikkommission Nordwest-und Zentralschweiz), Switzerland (reference 2015-401). As shock will be the common general condition among patients, informed consent by the patient him-/herself will not be possible in most cases. In this case, a nominated (study-independent physician) and, if available, a personal consultee (next of kin) will evaluate the patient’s enrolment in our study and sign as a representative. As soon as the patient regains the capacity, his/her informed consent will be sought.Dryad identifier:doi:;Protocol version:Version 2, 06.12.2015

: Not applicable.

: The authors declare that they have no competing interests.

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