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Article History

Received: 1 May 2025

Accepted: 2 October 2025

First Online: 4 December 2025

Declarations

:

: Not applicable.

: The datasets collected during this study are under the ownership of AbbVie or Simtra BioPharma Solutions and upon reasonable request can only be released after a company-internal approval process has been completed with positive outcome.

: Norbert Nagel, Stefan Weber, Javier Rueda Arregui and Evgenyi Shalaev are employees of AbbVie and may own AbbVie stock. Kevin Bond is an employee of Simtra BioPharma Solutions and may own Simtra BioPharma Solutions stock. The design, study conduct, and financial support for this research were provided by AbbVie and Simtra BioPharma Solutions. AbbVie and Simtra BioPharma Solutions participated in the interpretation of data, review, and approval of the publication.

: AbbVie and Simtra BioPharma Solutions sponsored the study; contributed to the design; participated in the collection, analysis, and interpretation of data; in writing, reviewing, and approval of the final version. No honoraria or payments were made for authorship.

: The authors gratefully acknowledge support in formatting the manuscript by Tamara Nicklis.

: Not applicable.

: Not applicable.