Grove, Jane I. http://orcid.org/0000-0002-9950-7201
Stephens, Camilla http://orcid.org/0000-0002-0796-9610
Lucena, M. Isabel http://orcid.org/0000-0001-9586-4896
Andrade, Raúl J. http://orcid.org/0000-0002-1565-0757
Weber, Sabine
Gerbes, Alexander http://orcid.org/0000-0003-0440-7417
Bjornsson, Einar S. http://orcid.org/0000-0002-8392-0632
Stirnimann, Guido http://orcid.org/0000-0003-3447-264X
Daly, Ann K. http://orcid.org/0000-0002-7321-0629
Hackl, Matthias http://orcid.org/0000-0002-4136-7293
Khamina-Kotisch, Kseniya http://orcid.org/0000-0002-7363-7905
Marin, Jose J. G.
Monte, Maria J. http://orcid.org/0000-0003-1844-7428
Paciga, Sara A. http://orcid.org/0000-0002-2495-5982
Lingaya, Melanie http://orcid.org/0000-0002-9390-2315
Forootan, Shiva S.
Goldring, Christopher E. P.
Poetz, Oliver
Lombaard, Rudolf
Stege, Alexandra http://orcid.org/0000-0001-9659-1930
Bjorrnsson, Helgi K.
Robles-Diaz, Mercedes http://orcid.org/0000-0002-2365-2787
Li, Dingzhou
Tran, Thi Dong Binh
Ramaiah, Shashi K.
Samodelov, Sophia L. http://orcid.org/0000-0003-1955-6060
Kullak-Ublick, Gerd A. http://orcid.org/0000-0002-0757-4408
Aithal, Guruprasad P. http://orcid.org/0000-0003-3924-4830
,
Funding for this research was provided by:
NIHR Nottingham Biomedical Research Centre (BRC-1215-20003, NIHR203310)
Innovative Medicines Initiative (821283)
Article History
Received: 29 March 2023
Accepted: 8 August 2023
First Online: 12 September 2023
Declarations
:
: Ethical approvals were obtained from local ethical review authorities for each of the recruiting locations as listed in Table InternalRef removed. Studies are conducted according to the Declaration of Helsinki (Hong Kong Amendment) and Good Clinical Practice (European guidelines) with all participants providing written informed consent or with written informed consent from a personal consultee in specified circumstances when participants lack capacity to give informed consent.
: Not applicable.
: Matthias Hackl is shareholder of TAmiRNA GmbH. Kseniya Khamina-Kotisch is employed by TAmiRNA GmbH. Oliver Poetz is shareholder of SIGNATOPE GmbH. Gerd A. Kullak-Ublick holds Novartis equity. Dingzhou Li, Thi Dong Binh Tran and Shashi K. Ramaiah are employed by Pfizer. Guruprasad P. Aithal has received consulting fees from Pfizer, GlaxoSmithKline, Clinipace, Servier Pharmaceuticals, NUCANA Plc, AstraZeneca and BenevolentAI paid to the University of Nottingham. The other authors declare that they have no competing interests.