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Article History

Received: 1 October 2017

Accepted: 6 February 2018

First Online: 21 February 2018

Ethics approval and consent to participate

: This project was reviewed and approved by an institutional review board and all procedures were in accordance with the ethical standards of the 1964 Helsinki declaration and its later amendments. Written informed consent was obtained from all participants prior to study participation.

: Not applicable — this manuscript does not contain any individual person’s data.

: Declaration of personal interests: Sandy Lewis, Carla DeMuro, and Valerie Williams are employees of RTI Health Solutions. Stan L. Block is an employee of Kentucky Pediatric & Adult Research. Richard Schwartz is an employee of Advanced Pediatrics. Shelly Senders is an employee of Senders Pediatrics. Paul Wisman is an employee of Pediatric Research of Charlottesville. Seth Toback was an employee of Gilead Sciences Inc. at the time this work was conducted. Jason Chien is an employee of Gilead Sciences Inc.Declaration of funding interests: The study was conducted by RTI Health Solutions, which received consultancy fees from Gilead Sciences Inc. RTI Health Solutions designed the study in collaboration with Gilead; RTI Health Solutions collected, analyzed, and interpreted the data; RTI Health Solutions and Gilead were involved in the decision to submit these data for publication. Funds for the preparation of this manuscript were provided by Gilead Sciences Inc. Results of this research were not contingent on the sponsor’s approval of the manuscript. RTI Health Solutions is a research unit of RTI International, a not-for-profit research institute.

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