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Authors
Vernon, Margaret K.
Munera, Catherine
Spencer, Robert H.
Wen, Warren
Menzaghi, Frédérique https://orcid.org/0000-0002-3584-1665
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Funding
Funding for this research was provided by:
Cara Therapeutics (Cara Therapeutics)
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Article History
Received: 20 December 2024
Accepted: 12 November 2025
First Online: 27 November 2025
Declarations
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: This study was approved by an Institutional Review Board (Advarra Inc., MD, US) and recruitment procedures complied with Health Insurance Portability and Accountability Act regulations. The original trials were conducted in accordance with the principles of the Declaration of Helsinki, the International Conference on Harmonisation guidelines for Good Clinical Practice, and applicable regulatory requirements. The trial protocols were approved by the institutional review board at each participating institution. All participants provided their written informed consent.
: Not applicable.
: MKV was employed by Evidera when the study was conducted. FM, CM, WW, and RHS were employed by Cara Therapeutics, Inc. when the study was conducted.
