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Article History

Received: 23 July 2025

Accepted: 2 March 2026

First Online: 13 March 2026

Declarations

:

: The CARTITUDE-4 study (NCT04181827) was conducted in accordance with the principles of the Declaration of Helsinki and the International Conference on Harmonisation guidelines for Good Clinical Practice. An independent ethics committee or institutional review board at each site approved the protocol before study-related procedures commenced.

: All patients provided written informed consent before enrollment into the CARTITUDE-4 study.

: Not applicable.

: R Mina reported a consulting role, advisory role, or honoraria for Amgen, BMS/Celgene, GSK, Janssen, Menarini-Stemline, Pfizer, Sanofi, and Takeda. H Yokoyama reported honoraria for Astellas. W Alsdorf reported honoraria, research funding, or travel expenses for Affimed, BioNTech, GSK, Immatics, and Janssen. L Shune reported a consulting role or advisory role for MS and J&J. I Isufi reported a consulting role for AbbVie, ADC Therapeutics, Beam Therapeutics, Genmab, Gilead, and Incyte as well as holding equity in Gilead. SJ Harrison reported consulting roles, advisory roles, honoraria, research funding, or speaker’s bureau for AbbVie, Amgen, Celgene/BMS, Eusa, F. Hoffmann-La Roche Ltd./Genentech, Inc., GSK, HaemaLogiX, Janssen, Novartis, and Terumo BCT. UA Shah reported receiving support in part from National Institutes of Health/National Cancer Institute Cancer Center grant P30CA008748; research funding support from Celgene/BMS and Janssen to the institution; and personal fees from Janssen Biotech, Sanofi, BMS, and i3Health outside the submitted work. AD Champlain, EG Katz, KS Gries, Dr Lendvai, and A Slaughter have equity and stock options in Janssen and are employed by Janssen. JM Schecter has stock and other ownership interests in Johnson & Johnson and is currently employed by Janssen. C Lonardi and W Deraedt are employed by Janssen. OC Costa Filho and N Patel have equity in Legend Biotech USA Inc. and are employed by Legend Biotech USA Inc. E Florendo is employed by Legend Biotech USA Inc. K Fai Ho reported a consulting role for Janssen. L Karlin reported a consulting role or honoraria for AbbVie, Amgen, Celgene, GSK, Janssen, Sanofi, and Takeda. K Weisel reported a consulting role, honoraria, or research funding for AbbVie, Amgen, Adaptive Biotech, AstraZeneca, BeiGene, BMS/Celgene, GSK, Janssen, Karyopharm, Menarini, Novartis, Oncopeptides, Pfizer, Roche, Sanofi, Stemline, and Takeda. No other disclosures were reported.