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Article History

Received: 7 December 2017

Accepted: 17 January 2018

First Online: 27 February 2018

Authors’ information

: AR is a Paediatric Rheumatologist at Bristol Royal Hospital for Children and Royal National Hospital for Rheumatic Diseases, Bath, UK. AD is Professor of Ophthalmology, University of Bristol, Duke Elder Professor of Ophthalmology, UCL Institute of Ophthalmology and Joint Director of Research for Moorfields Eye Hospital and Institute of Ophthalmology, UK. CG is a Consultant Ophthalmologist at the Bristol Eye Hospital, Bristol, UK. BH is a Trial Co-ordinator at the Clinical Trials Research Centre, University of Liverpool, Liverpool, UK. HH is Head of Trial Management at the Clinical Trials Research Centre, University of Liverpool, Liverpool, UK. AJ is a Senior Statistician at the Clinical Trials Research Centre, University of Liverpool, Liverpool, UK. RL is a Clinical Lecturer in Ophthalmology at the Bristol Eye Hospital, Bristol, UK. AM is a Statistician at the Clinical Trials Research Centre, University of Liverpool, Liverpool, UK. MB is Brough Chair and Professor of Child Health, University of Liverpool, Director of the Arthritis Research UK Experimental Arthritis Treatment Centre for Children, Director of the NIHR Alder Hey Experimental Arthritis Treatment Centre, academic lead for the Clinical Academic Department of Paediatric Rheumatology at Alder Hey Children’s NHS Foundation Trust, Liverpool, UK and Specialty Cluster Lead of the NIHR CRN National Coordinating Centre Hub including the National Specialties of Children and Musculoskeletal research.

: Full ethical approval has been gained from the National Research Ethics Service Committee London – South East (15/LO/0771). Full approval has also been gained from the Medicines and Healthcare Products Regulatory Agency (European Clinical Trials Database number 2015–001323-23). This trial recruits minors and young people under the age of 16 years. Informed consent procedures reflected the legal and ethical requirements to obtain valid informed consent for this population. Prior written informed consent is required for all trial participants. In obtaining and documenting informed consent, the investigator complies with applicable regulatory requirements and adheres to Good Clinical Practice and to the ethical principles that have their origin in the Declaration of Helsinki.

: Not applicable

: The authors declare that they have no competing interests.

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