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Article History

Received: 5 July 2023

Accepted: 27 September 2023

First Online: 8 November 2023

Declarations

:

: All animal experiments were performed under the guidelines of the Institutional Animal Care and Use Committees of the Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, and the Institute for Genetic Medicine, Hokkaido University. The protocols for animal experiments were all approved by the Institutional Animal Care and Use Committees of the Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, and the Institute for Genetic Medicine, Hokkaido University. Ethical approval for the clinical studies was granted by institutional review board of Hokkaido University Hospital and that of Kitasato University School of Medicine. and for the animal experiments and clinical studies was granted by the Institutional Animal Care and Use Committees of Hokkaido University (approval number: 14–0083). These studies are according to the Declaration of Helsinki. Participants gave informed consent to participate in the study before taking part.

: Not appreciable.

: All authors declare they have no competing interests.