Document is current

Article History

Received: 25 October 2019

Accepted: 8 November 2019

First Online: 13 December 2019

Ethics approval and consent to participate

: The study protocol conforms to the principles of the declaration of Helsinki and was approved by the ethic committees of local medical faculty. The leading ethic committee was located at the Medical Faculty of the University of Münster (reference number 2014–398-f-S). All participants are obliged to hand in the signed informed consent form (ICF).

: Not applicable.

: LB has no competing interests. TR reports grants from German Ministry of Education, Science, Research and Technology, during the conduct of the study; grants and personal fees from Sanofi Genzyme, personal fees from Biogen, personal fees and non-financial support from Merck Serono, personal fees from Roche, personal fees from Teva, outside the submitted work. SP reports personal fees and non-financial support from Sanofi Genzyme, personal fees from Biogen, personal fees and non-financial support from Merck Serono, personal fees from Mylan, and grants from Diamed, outside the submitted work CCG reports grants from German Ministry of Education, Science, Research and Technology, grants from Collaborative Research Centre CRC TR128, during the conduct of the study; personal fees from Sanofi Genzyme, grants from Biogen, personal fees from Bayer Health Care, grants from Novartis, grants from Euroimmun, personal fees from Mylan, outside the submitted work.HW reports grants from German Ministry of Education, Science, Research and Technology, grants from Collaborative Research Centre CRC TR128, during the conduct of the study; grants and personal fees from Biogen, personal fees from Eygen, personal fees from Merck Serono, personal fees from Novartis, grants and personal fees from Roche, grants and personal fees from Sanofi Genzyme, personal fees from Teva, grants from GlaxoSmithKline, personal fees from WebMD Global, personal fees from Abbvie, personal fees from Alexion, personal fees from Acetelion, personal fees from Swiss Multiple Sclerosis Society, outside the submitted work. SGM reports grants from German Ministry of Education, Science, Research and Technology, during the conduct of the study; personal fees from Almirall, personal fees from Bayer Health Care, grants and personal fees from Biogen, grants and personal fees from Diamed, personal fees from Fresenius Medical Care, grants and personal fees from Sanofi Genzyme, grants and personal fees from Merck Serono, personal fees from Novartis, grants and personal fees from ONO Pharma, personal fees from Roche, personal fees from Teva, outside the submitted work.