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Authors
Liu, Ju
Yang, Jingzhi
Tang, Jianing
Tang, Hongxia
Dai, Xin
Jin, Peiyao
Huang, Yanmei
Li, Zhenzhen
Zhang, Ziyin
Guo, Xiaohuan
Bitzan, Martin
Yin, Xiaoling
Liu, Chaohong https://orcid.org/0000-0001-7028-4625
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Funding
Funding for this research was provided by:
International scientific and technological innovation cooperation between governments from Ministry of Science and Technology of the People's Republic of China (2021YFE0108200)
National Natural Science Foundation of China (NSFC32311530061)
National Natural Science Foundation of China (32100709)
National Natural Science Foundation of China (82371784)
National Key R&D Program of China (2023YFC2507900)
National Key R&D Program of China (2023YFC2706300)
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Article History
Received: 21 December 2024
Revised: 11 September 2025
Accepted: 15 September 2025
First Online: 10 November 2025
Declarations
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: Three patients with STAT3 gene mutations and nine age- and sex-matched healthy controls were enrolled in the study from Tongji Hospital and Wuhan Children’s Hospital. The parents of all participants provided written informed consent, approved by the ethics committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Ethical approval number: 2025-S108). The animals used in our experiments were approved by the Animal Ethics Committee of Huazhong University of Science and Technology, approval number is 4783.
: The authors declare that they have no relevant conflicts of interest.
