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HMGB1 aggravates neuronal ferroptosis and microglial inflammation in metabolic syndrome-associated cognitive impairment via the NRF2-autophagic flux axis

Crossref DOI link: https://doi.org/10.1186/s43556-026-00548-8

Published Online: 2026-08-18

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhang, Xin

Zhang, Yue

Tang, Meng-Meng

Zhang, Jia-Mei

Xiao, Ya-Qin

Yang, Jian-Jun

Liu, Cun-Ming

Yu, Min https://orcid.org/0009-0009-6506-5685
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82001141)

Natural Science Foundation of Jiangsu Province (BK20201084)

Natural Science Foundation of Jiangsu Province (BK20211382)

National Natural Science Foundation of China (U23A20421)
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Article History

Received: 2 August 2025

Revised: 26 July 2026

Accepted: 3 August 2026

First Online: 18 August 2026

Declarations

Ethics approval and consent to participate: The animal experiments of the present study were approved by the Experimental Animal Ethics Committee of Nanjing Medical University (IACUC-2212042) and followed the Guide for the Care and Use of Laboratory Animals.

Consent for publication: Not applicable.

Competing interests: The authors declare no conflict of interest.

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