Funding for this research was provided by:
National Institute on Aging (R01AG031110, U54HD090256, U01AG0514.)
National Institutes of Health (T32CA009206)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54 HD090256)
Received: 10 February 2021
Accepted: 8 April 2021
First Online: 20 April 2021
: Consent or assent for study participation was obtained from all adults with DS. Proxy consent was obtained from caregivers who served as legal guardians.
: Not applicable.
: GE Healthcare holds a license agreement with the University of Pittsburgh based on the PiB PET technology described in this manuscript. Dr. Klunk is a co-inventor of PiB and, as such, has a financial interest in this license agreement. GE Healthcare provided no grant support for this study and had no role in the design or interpretation of results or preparation of this manuscript. All other authors have no PiB-related conflicts of interest with this work and had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.