Funding for this research was provided by:
European Research Council (637640)
Received: 23 June 2020
Accepted: 22 December 2020
First Online: 15 March 2021
Ethics approval and consent to participate
: Written informed consent was obtained previously from all participants of the LL, LLS, NTR and RS biobanks in accordance with the ethical and institutional regulations. The LL study was approved by the Medical Ethics committee of the University Medical Centre Groningen (METc UMCG) document number METC UMCG LLDEEP: M12.113965) [CitationRef removed]. The study protocol for LLS was approved by the Medical Ethical committee of the Leiden University Medical Center (METC-LDD) before the start of the study [CitationRef removed]. The NTR study protocol was approved by Central Ethics Committee on Research Involving Human Subjects of the VU University Medical Center (CCMO), Amsterdam, an Institutional Review Board certified by the US Office of Human Research Protections (IRB number IRB2991 under Federal-wide Assurance-3703; IRB/institute codes, NTR 03–180) [CitationRef removed]. The RS was approved by the Medical Ethics Committee of the Erasmus MC (Erasmus MC MERC, registration number MEC 02.1015) and by the Dutch Ministry of Health, Welfare and Sport (Population Screening Act WBO, license number 1071272–159521-PG) [CitationRef removed]. According to the METc UMCG, the study described in this manuscript is not a clinical research with human subjects as meant in the Medical Research involving Human Subjects Act (WMO). Therefore, no additional WMO approval of the study was required.
: Not applicable.
: The authors declare no conflict of interest.