Funding for this research was provided by:
Japan Society for the Promotion of Science (JP18H05280)
Canon Foundation in Europe
Grant-in-Aid for Scientific Research (6K00944)
Health and Labour Sciences Research Grant (201709002B)
the Japan Agency for Medical Research and Development (JP20gm1010006h004)
the Ministry of Health and Welfare of Japan and Public/Private R&D Investment Strategic Expansion Program: PRISM
Received: 29 October 2020
Accepted: 4 May 2021
First Online: 20 May 2021
: NIBIOHN cohort study was approved by the Ethics Committee of National Institutes of Biomedical Innovation, Health and Nutrition (Approval No. KENEI3–06, KENEI78–05, KENEI116, 154–09, 177–07, Osaka, Japan) and MORINAGA cohort study was approved by the Ethics Committee of Japan Conference of Clinical Research (Approval No. 246, Tokyo, Japan), in accordance to their respective guidelines.Signed informed consent was obtained from all participants.
: Not applicable.
: The authors of this manuscript have the following competing interests: Kumiko Kato, Jin-zhong Xiao and Toshitaka Odamaki are employees of Morinaga Milk Industry Co., Ltd.