Funding for this research was provided by:
National Medical Research Council (NHIC-I2D-1409017)
Received: 5 July 2019
Accepted: 28 May 2020
First Online: 8 June 2020
Ethics approval and consent to participate
: This study was approved by the SingHealth Centralized Institutional Review Board, Singapore (SingHealth CIRB Ref: 2015/3062), and registered on ExternalRef removed (NCT02804022). Written informed consent was obtained from all participants prior to start of the study. This work was conducted in accordance with the Declaration of Helsinki.
: Not applicable.
: Ban Leong Sng is an associate editor of BMC Anesthesiology. Ban Leong Sng and Alex Sia Tiong Heng have filed a patent related to this work (SG 10201801161P, filed 12 Feb 2018, Singapore). Alex Sia Tiong Heng has intellectual property ownership and is the founding scientific director of Innovfusion Pte Ltd. All other authors reports no conflicts of interest in this work.