Funding for this research was provided by:
Japan Society for the Promotion of Science (16H01862)
Received: 25 June 2018
Accepted: 25 July 2018
First Online: 2 August 2018
Ethics approval and consent to participate
: The study protocol of FLAGSHIP was organized according to the Guidelines for the Epidemiological Research proposed by the Japanese Ministry of Health, Labour and Welfare. Additionally, the study protocol was approved by the ethics committee of Nagoya University School of Medicine (approval no. 2014–0421). Ethical approval was also obtained from each participating hospital (Additional file InternalRef removed), and each patient provided written informed consent to be registered to this study. Treatment methods and hospital care for the patients are not altered due to participation in this study.
: Not applicable.
: No conflict of interest declared.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.