Funding for this research was provided by:
National Institute for Health Research (14/183/08)
Received: 2 July 2018
Accepted: 7 February 2019
First Online: 21 February 2019
Ethics approval and consent to participate
: The study has been granted a favourable ethical opinion by Newcastle and North Tyneside 1 NRES Committee (16/NE/0123). Newcastle University acted as trial sponsor. The SOLID Management Group have been responsible for ensuring the appropriate and timely implementation of the trial. A Trial Oversight Committee has been appointment to oversee trial progress with particular attention paid to recruitment, retention, adherence to trial protocol, participant safety and any new information deemed relevant to the research question.Written informed consent was obtained for all participants, inclusive of assent from LAC under 16 years of age and consent from their corporate guardian.
: Not applicable.
: The authors declare that they have no competing interests.
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