Funding for this research was provided by:
Medical Research Council (MR/N028287/1, MR/N028287/1, MR/N028287/1, MR/N028287/1, MR/N028287/1)
Received: 5 October 2018
Accepted: 22 April 2019
First Online: 14 May 2019
Ethics approval and consent to participate
: The OSCAR trial was approved by UK ethics review committees and research governance departments at each participating centre (Multicentre Research Ethics Committee: 07/H0502/98). Patients or their representatives provided written consent. Additional ethics approval was not sought to perform this secondary analysis.
: Not applicable.
: The authors declare that they have no competing interests.
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