Funding for this research was provided by:
Research Trainees Coordinating Centre (PDF-2015-08-044)
National Institute for Health Research (Collaboration for Leadership in Applied Health Research and Care North West Coast (NIHR CLAHRC NWC))
Received: 15 March 2019
Accepted: 31 March 2020
First Online: 15 April 2020
Ethics approval and consent to participate
: SANAD received appropriate multicentre and local ethics and research committee approvals from the National Multi-Centre Research Ethics Committee North West (MREC 98/8/62), and was managed according to the Medical Research Council’s Good Clinical Practice Guidelines. Patients gave informed written consent to inclusion and to long-term follow-up. In the case of children (< 16 years), consent was obtained from the parent or guardian.SANAD is registered as an International Standard Randomised Controlled Trial, number ISRCTN38354748.
: Not applicable.
: The authors declare that they have no competing interests.