Received: 15 February 2021
Accepted: 17 August 2021
First Online: 17 October 2021
: This meta-analysis was undertaken using fully anonymised individual patient data shared from randomised clinical trials that each had their own research ethics committee approvals and consents for data sharing. The anonymised data from each trial were shared after a data sharing agreement was completed and signed by the data owner (or an appropriate representative) and the representative for the Collaboration (PMB). An ethics and consent waiver for this research was granted on 22nd July 2015 by the School of Medicine Research Ethics Committee, University of Nottingham (Reference: DB21072015 SoM CN).
: Not applicable.
: PMB is Stroke Association Professor of Stroke Medicine and is a NIHR Senior Investigator. PMB was Chief Investigator for the ENOS and TARDIS trials, which were shared with the study. LJW was funded in part by UK MRC ENOS (G0501797) and NIHR TARDIS (10/104/24). AAM, JM, BRD, AA, J-LM, JAS, LT AT, AK, SJP, JC, GJH, JDS, PS, HCS, SU & NS report no conflicts of interest.