Received: 15 April 2021
Accepted: 11 January 2022
First Online: 3 April 2022
: Ethical approval was not sought for the simulation study as this was not deemed necessary. The applied example used secondary data from the CPRD. The study protocol for the original study was approved by the CPRD's Independent Scientific Advisory Committee (approval no. 11_113R).
: Not applicable.
: WGD has received consultancy fees from Bayer, Abbvie and Google, unrelated to this work.AM, GD and RE declare no conflicts of interest.