Funding for this research was provided by:
Japan Agency for Medical Research and Development (18fk0210020h0002)
Text and Data Mining valid from 2019-10-24
Received: 10 June 2019
Accepted: 11 October 2019
First Online: 24 October 2019
Ethics approval and consent to participate
: All participants provided written informed consent to participate in the study according to the process approved by the ethical committee of Hiroshima University and conforming to the ethical guidelines of the Declaration of Helsinki.
: Not applicable. The authors declare that no patient data (details, images or videos relating to individual participants) are included in this article.
: Michio Imamura has received research funding from Bristol-Myers Squibb. Kazuaki Chayama has received honoraria from Bristol-Myers Squibb, MSD K.K., AbbVie Inc., Gilead Sciences and Dainippon Sumitomo Pharma and research funding from Dainippon Sumitomo Pharma, MSD K. K and AbbVie Inc..